Synthesis, Characterization and Antibacterial Activity of Complexes of Lanthanide(III) Nitrates with 2-Chloro-10-[3-(Diethylamino)Propyl]-Phenothiazine

Abstract

Fourteen new complexes of lanthanide(III) nitrates with 2-chloro-10-[3-diethylaminopropyl]phenothiazine (chlorproethazine) of the type [Ln(CPE)₂(NO₃)₂]NO₃ (where Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb. Dy. Ho, Er, Tm. Yb, Lu and CPE = chlorproethazine) have been synthesised and characterised on the basis of elemental analyses, magnetic moments, molar conductance measurements, IR, electronic spectra, TG and DTA. The analytical data suggest the Ln³⁺ ions are eight-coordinate. The nephelauxetic ratios (β), bonding parameters (b^1/2), Sinha's parameters (δ%) and covalency angular overlap parameters (η) have been calculated for the Pr(III), Nd(III) and Er(III) complexes. The complexes have been screened for their antibacterial activities against four bacteria.