Synthesis and Characterization of Novel Trans-Mixed Diamine Platinum(II) and Platinum(IV) Complexes

S. Shamsuddin Department of Experimental Therapeutics, The University of Texas, M. D. Anderson Cancer Center, Box 353, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

Mohammad Ali Department of Experimental Therapeutics, The University of Texas, M. D. Anderson Cancer Center, Box 353, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

S. Huang Department of Experimental Therapeutics, The University of Texas, M. D. Anderson Cancer Center, Box 353, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

Abdul Khokhar Department of Experimental Therapeutics, The University of Texas, M. D. Anderson Cancer Center, Box 353, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

A series of novel trans-mixed diamine platinum(II) and platinum(IV) complexes of type trans-[Pt^II(R-NH₂)(R'-NH₂)Cl₂] and trans -[Pt^IV(R-NH₂)(R'-NH₂)Cl₄] (where R-NH₂ = ethylamine or butylamine and R'-NH₂ = methylamine, propylamine, isopropylamine, pentylamine, or hexylamine) was synthesized and characterized using elemental analysis and infrared and ¹⁹⁵Pt nuclear magnetic resonance spectroscopic techniques.

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Synthesis and Characterization of Novel Trans-Mixed Diamine Platinum(II) and Platinum(IV) Complexes

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