Synthesis, spectral characterization and biological activity of benzofuran Schiff bases with Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes

Abstract

New Schiff bases have been synthesized from benzofuran-2-carbohydrazide and benzaldehyde, [BPMC] or 3,4-dimethoxybenzaldehyde, [BDMeOPMC]; complexes of the type MLX₂, where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), L = BPMC or BDMeOPMC and X = Cl, have been prepared. Structures have been elucidated on the basis of elemental analysis, conductance measurements, magnetic properties, spectral studies i.e., ¹H NMR, electronic, ESR and IR studies show that the Schiff bases are bidentate through the azomethine nitrogen and oxygen of the carbonyl. We propose tentative structures for all of these complexes. The antifungal and antibacterial activities of the ligands and their metal complexes have been screened against fungi Aspergillus niger and Aspergillus fumigatus and against bacteria Escherichia coli and S. aurious.

Keywords:

• Benzofuran Schiff bases
• Metal complexes
• Spectral studies
• Biological activity

Acknowledgement

The authors are thankful to the Chairman, Department of Chemistry, Gulbarga University, Gulbarga, Karnataka, India, for providing the necessary laboratory facilities and the Department of Microbiology, Gulbarga University, Gulbarga, for biological study.