Bis-(3,5-dimethyl-pyrazolyl-1-methyl)-(3-phosphanyl-propyl)-amine complexes of copper(II), nickel(II), and cobalt(II)

Abstract

A series of Cu(II), Co(II), and Ni(II) complexes of bis-(3,5-dimethyl-pyrazolyl-1-methyl)-(3-phosphanyl-propyl)-amine C₁₅H₂₆N₅P (1), prepared from 3-aminopropylphosphine and 1-hydroxymethyl-3,5-dimethylpyrazole were characterized. The nature of bonding and the geometry of the complexes have been deduced from elemental analysis, infrared, electronic, ¹H NMR, ³¹P NMR spectra, magnetic susceptibility, and conductivity measurements. The studies indicate octahedral geometry for nickel complex and square pyramidal geometry for copper and cobalt complexes. The EPR spectra of copper complex in acetonitrile at 300 K and 77 K were recorded. Biological activities of the ligand and metal complexes have been studied on Staphylococcus aureus, Escherichia coli, Aspergillus niger, and Aspergillus flavus by well-diffusion method. The zone of inhibition values were measured at 37°C for a period of 24 h. The electrochemical behavior of copper complexes was studied by cyclic voltammetry. Catalytic study indicates the copper complex has efficient catalytic activity in oxidation of amitriptyline.

Keywords:

• 3-Aminopropylphosphine
• 1-Hydroxy-3,5-dimethylpyrazole
• Metal complexes
• Catalytic activity

Acknowledgements

The authors are grateful to the management of Thiagarajar College of Arts and Science for their support. One of the authors (PT) thanks the Defence Research and Development Organisation (DRDO), New Delhi, for financial support.