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Journal of Coordination Chemistry Volume 62, 2009 - Issue 9
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Original Articles

Zinc(II) complexes of 2-pyridine-derived N(4)-p-tolyl thiosemicarbazones: study of in vitro antibacterial activity

Jeferson G. Da Silva Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
,
Solange M.S.V. Wardell Departamento de Síntese Orgânica, Farmanguinhos–Fiocruz, Instituto de Tecnologia em Fármacos, Far-Manguinhos, Fiocruz, Rio de Janeiro, Brazil
,
James L. Wardell Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
&
Heloisa Beraldo Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilCorrespondence[email protected]
Pages 1400-1406 | Received 25 Jul 2008, Accepted 19 Sep 2008, Published online: 25 Mar 2009
 
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Abstract

Reaction of N(4)-p-tolyl-2-formylpyridine thiosemicarbazone (H2Fo4pT), N(4)-p-tolyl-2-acetylpyridine thiosemicarbazone (H2Ac4pT), and N(4)-p-tolyl-2-benzoylpyridine thiosemicarbazone (H2Bz4pT) with ZnCl2 gave [Zn(H2Fo4pT)Cl2] (1), [Zn(H2Ac4pT)Cl2] (2), and [Zn(H2Bz4pT)Cl2] (3). In the first two complexes a tridentate Npy–N–S thiosemicarbazone binds to the zinc while in the latter N–S coordination occurs. Upon coordination the antibacterial activity against Salmonella typhimurium increases in 1 and 3.

Acknowledgments

This work was supported by CNPq and Instituto do Milênio-Inovação e Desenvolvimento de Novos Fármacos e Medicamentos (IM-INOFAR, Proc. CNPq 420015/05-1).

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Related Research Data

Synthesis and structural characterization of a new polymeric zinc(II) complex with thiophene-2-carboxylic acid
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