Synthesis, characterization, and biological activity of a Schiff-base Zn(II) complex

Abstract

Preparation and crystal structure of {4-chloro-2-[(2-morpholinoethylimino)methyl]phenolato} methanolchlorozinc(II) are reported. The X-ray structure reveals highly distorted square pyramidal geometry around zinc, binding to one phenolate O and two imine N atoms of the Schiff base, one methanol and one chloride. The complex and its ligand were tested in vitro for antibacterial and cytotoxic activity with a wide range of bactericidal activity and significant cytotoxic activity.

Keywords:

• Shiff base
• Zn(II) complex
• Crystal structure
• Antibacterial
• Cytotoxic

Acknowledgements

The work was financed by a grant (Project 30772627) from the National Natural Science Foundation of China.