Interaction of Naproxen with transition metals: synthesis, characterization, anti-inflammatory activity and kinetic studies

Abstract

Coordination complexes of transition metals (Co, Ni, Cu, Fe, Cr, Ru, Ir, Mn, and Zn) with 6-methoxy-α-methyl-2-naphthalene acetic acid (Naproxen) and triphenylphosphine have been synthesized and characterized by conductance, elemental analysis, UV-Vis, AAS, and FT-IR spectroscopy. The elemental analyses data reveal the presence of 1:1 (metal : ligand) stoichiometry and the IR data suggest that naproxen functions as a bidentate ligand in coordination with transition metals. The anti-inflammatory assays of these complexes have significant effect.

Keywords:

• Naproxen
• Transition metal complexes
• IR
• UV-Vis
• AAS

Acknowledgement

SA is thankful to Quaid-i-Azam University, Islamabad for financial support.