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Abstract
4-Methyl-2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline) (MHPIP) and its complexes [Co(bpy)2MHPIP]3+ (1) (bpy = 2,2′-bipyridine), [Co(dmb)2MHPIP]3+ (2) (dmb = 4,4′-dimethyl-2,2′-bipyridine), and [Co(phen)2MHPIP]3+ (3) (phen = 1,10-phenanthroline) have been synthesized and characterized by UV/VIS, IR, EA, 1H, 13C-NMR, and mass spectra. The binding of the three complexes with calf-thymus-DNA (CT-DNA) has been investigated by absorption and emission spectroscopy, DNA-melting techniques, viscosity measurements, and DNA cleavage assay. The spectroscopic data and viscosity results indicate that these complexes bind to CT-DNA via an intercalative mode. The complexes also promote photocleavage of plasmid pBR322 DNA and were screened for antimicrobial activity.
Acknowledgement
The financial support from UGC (New Delhi) is gratefully acknowledged.
