Synthesis, spectroscopic characterization, and antibacterial assays in vitro of a new platinum(II) complex with methionine sulfoxide

Abstract

A new platinum(II) complex with methionine sulfoxide was synthesized and characterized by chemical and spectroscopic techniques. Elemental analyses, mass spectrometric measurements (electrospray ionization quadrupole time-of-flight mass spectrometry), and thermal analyses of the solid compound fit the composition [(C₅H₁₀NO₃S)Pt(µ-Cl)₂Pt(C₅H₁₀NO₃S)] · 2.5H₂O. Infrared spectroscopic data indicate coordination of the ligand to Pt(II) through the nitrogen of NH₂ and the sulfur of the S=O group. ¹H-¹⁵N nuclear magnetic resonance spectroscopic data confirm nitrogen coordination. Antibacterial activities were evaluated by antibiogram assays using the disc diffusion method. The platinum(II) complex showed antibacterial activity against Gram-negative Pseudomonas aeruginosa bacterial cells.

Keywords:

• Platinum(II)
• Methionine sulfoxide
• NMR spectroscopy
• Mass spectrometry
• Antibacterial activity

Acknowledgments

This study was supported by grants from FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo – Brazil, proc. 2010/00534-7 and 2006/55367-2), FAEPEX, and CNPq.