Synthesis, characterization, and biological activity of complexes derived from E-N′-(3,4,5-trimethoxybenzylidene)benzofuran-2-carbohydrazide and ortho-phenylenediamine/ 2,6-diaminopyridine

Abstract

Mixed ligand complexes of the type MLL′Cl₂ (where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II), L = ligand derived from the reaction between benzofuran-2-carbohydrazide and 3,4,5-trimethoxybenzaldehyde (TMeOBFC), and L′ = ortho-phenylenediamine (opd)/2,6-diaminopyridine (2,6-dap)) have been synthesized. The complexes have been characterized by analytical data, IR, UV-Vis, ¹H NMR, DART-MS and ESR spectral data, and magnetic studies. Molar conductance values indicate that the complexes are non-electrolytic in DMF. Antibacterial and antifungal activities of the ligands and complexes have been screened against bacteria Escherichia coli and Staphylococcus aureus and against fungi Aspergillus niger and Aspergillus flavus.

Keywords:

• Benzofuran Schiff bases
• Mixed ligand complexes
• Spectral studies
• Biological activity

Acknowledgments

Authors are thankful to Chairman, Department of Chemistry, Gulbarga University, Gulbarga, for encouragement and facilities. V.B. Patil is thankful to UGC New Delhi for UGC Research Fellowship for meritorious students under RFSMS Scheme.