Synthesis and characterization of chloro-bis(quinoline-2-carboxylato-κ²N,O)gallium(III)

Abstract

The preparation and characterization of a new gallium(III) complex with quinoline-2-carboxylate, of formula [Ga(quin-2-c)₂Cl], are described. The crystal structure of the complex has been determined by X-ray diffraction, crystallizing in monoclinic space group P2₁/n with Ga(III) adopting a distorted tetragonal pyramid. Gallium(III) coordinates two quinoline-2-carboxylates and one chloride with a Cl,N₂,O₂ donor set. In the crystal the 2-D supramolecular structure is generated by weak intermolecular interactions, C–H ··· O, C–H ··· Cl, and C–H ··· π. The cytotoxicity assays against several human cancer cell lines (Du145, A549, MCF-7, A498, HT-29) and against mouse fibroblasts (BALB/3T3) revealed moderate antiproliferative activity of the complex.

Keywords:

• Quinoline-2-carboxylate
• Gallium(III) complex
• Crystal structure
• Cytotoxic activity

Acknowledgments

The authors acknowledge financial support from Wrocław University of Technology.