Synthesis, structural and thermal studies of some biologically active antimony semicarbazones and thiosemicarbazones

Abstract

The reactions of Ph₃SbCl₂ and SbCl₃ with semicarbazone and thiosemicarbazone ligands resulted in Ph₃SbCl₂(L) and SbCl₃(L) (L = semicarbazone and thiosemicarbazone ligands). These complexes were characterized by elemental analyses, IR, ¹H and ¹³C {¹H} NMR spectral data, and conductometric measurements. On the basis of spectroscopic data, a seven-coordinate and a five-coordinate antimony with ligand coordination through oxygen/sulfur and azomethine nitrogen have been suggested for Ph₃SbCl₂(L) and SbCl₃(L), respectively. These compounds show antifungal and antibacterial activities. Thermal behavior of some of the adducts have been studied by thermogravimetric analyses. Thermal decomposition of Ph₃SbCl₂(L) and SbCl₃(L) resulted in micron size Sb and Sb₂S₃ particles. The materials obtained were characterized by powder X-ray diffraction patterns, scanning electron microscopy, and energy dispersive X-ray analysis (EDAX).

Keywords:

• Antimony complexes
• Antimony sulfide
• Semicarbazone
• Thiosemicarbazone
• Antifungal
• Antibacterial

Acknowledgments

Thanks are due to SAIF, IIT-Bombay for providing NMR spectra of the complexes, TIFR, Mumbai for SEM images and EDAX data.