Bimetallic organotin(IV) complexes with ferrocene-based azomethines: synthesis, characterization, semi-empirical study, and antibacterial activity

Abstract

A series of bimetallic organotin(IV) complexes with ferrocene-based azomethines (Schiff bases) were synthesized by reacting sodium salt of tranexamic acid, 4-amino butanoic acid, and phenyl alanine with trimethyltin and tributyltin chloride in 1 : 1 molar ratio under inert atmosphere. The synthesized trialkyl organotin complexes condense with formyl ferrocene under inert atmosphere to yield organotin(IV) ferrocenyl Schiff bases. Composition of the organotin(IV) complexes, bonding behavior of donor groups, and structural assignments were studied by elemental analysis, FT-IR, ¹H, ¹³C, ¹¹⁹Sn NMR, and mass spectrometry. The spectral data suggest that the ligand is bidentate, coordinating through oxygens. Spectroscopic techniques reveal distorted tetrahedral geometry in solution for the complexes. As solids, the complexes are trigonal bipyramidal, confirmed by semi-empirical study. Mass spectrometric and elemental analysis data support the solid and solution spectroscopic results. Bioactivity screenings show in vitro biological potential.

Keywords:

• Bimetallic
• Ferrocene-based azomethines
• Organotin
• IR
• NMR
• Mass
• Semi-empirical
• Antibacterial activity

Acknowledgment

SA is thankful to Quaid-i-Azam University, Islamabad, for financial support as URF.