Advanced search
Publication Cover
Journal of Coordination Chemistry Volume 64, 2011 - Issue 14
Submit an article Journal homepage
130
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis, crystal structure, DNA binding, and DNA cleavage of a zinc complex containing N,N-bis(2-pyridylmethyl)amine

Jing Qian College of Chemistry, Tianjin Normal University, Tianjin 300387, P.R. ChinaCorrespondence[email protected]
,
Li-Ping Wang Department of Chemistry, Baoding College, Baoding 071000, P.R. China
,
Wen Gu College of Chemistry, Nankai University, Tianjin 300394, P.R. China
,
Xin Liu College of Chemistry, Nankai University, Tianjin 300394, P.R. China
,
Jin-Lei Tian College of Chemistry, Nankai University, Tianjin 300394, P.R. China
&
Shi-Ping Yan College of Chemistry, Nankai University, Tianjin 300394, P.R. China
Pages 2480-2488 | Received 24 Mar 2011, Accepted 12 May 2011, Published online: 14 Jul 2011
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

A water-soluble zinc complex, [Zn(bpea)Cl2] (1) (bpea = N,N-bis(2-pyridylmethyl)ethylamine), was prepared to serve as a nuclease mimic. The complex was characterized by X-ray, infrared, and UV spectroscopy. Interactions of the complex with calf thymus-DNA (ct-DNA) have been investigated by UV absorption and fluorescence spectroscopies; the mode of ct-DNA binding for 1 has been proposed. DNA cleavage activities by 1 were performed in the absence of external agents. The influences of different complex concentrations or reaction times on DNA cleavage were studied.

Acknowledgments

Financial support from the National Natural Science Foundation of China (Grant No. 21001066), the PhD Science Foundation of Tianjin Normal University (Grant No. 52LX28), and the Education Science Foundation of Tianjin City (Grant No. 20070606) are gratefully acknowledged.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

RECOGNITION OF GUANINE STRUCTURE IN NUCLEIC ACIDS BY NICKEL COMPLEXES
Source: American Chemical Society (ACS)
Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)
Source: American Chemical Society (ACS)
CCDC 603567: Experimental Crystal Structure Determination
Source: Cambridge Crystallographic Data Centre
Toward the development of metal-based synthetic nucleases and peptidases: a rationale and progress report in applying the principles of coordination chemistry
Source: Elsevier BV
The first dinuclear copper(II) and zinc(II) complexes containing novel Bis-TACN: syntheses, structures, and DNA cleavage activities
Source: Royal Society of Chemistry (RSC)
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
Source: Elsevier BV
Crystal structures and magnetic behaviour of three new azido-bridged dinuclear cobalt(II) and copper(II) complexes
Source: Royal Society of Chemistry (RSC)
A zinc(II) complex with tris(2-( N -methyl)benzimidazlylmethyl)amine and salicylate: synthesis, crystal structure, and DNA-binding
Source: (:unav)
Oxidative Nucleobase Modifications Leading to Strand Scission
Source: American Chemical Society (ACS)
Chemical nucleases
Source: American Chemical Society (ACS)
Efficient Inorganic Deoxyribonucleases. Greater than 50-Million-Fold Rate Enhancement in Enzyme-Like DNA Cleavage
Source: American Chemical Society (ACS)
Synthesis, Structure, and Solution Equilibria of Diamagnetic and Paramagnetic Azooximates of Bivalent Platinum. Geometrical Change Associated with Ligand-Based Electroprotic Reactions
Source: American Chemical Society (ACS)
Long-range fluorescence quenching of ethidium ion by cationic porphyrins in the presence of DNA
Source: American Chemical Society (ACS)
Design of a Synthetic Nuclease: DNA Hydrolysis by a Zinc-Binding Peptide Tethered to a Rhodium Intercalator
Source: American Chemical Society (ACS)
A Further Examination of the Molecular Weight and Size of Desoxypentose Nucleic Acid
Source: American Chemical Society (ACS)
Dinuclear and tetranuclear iron(III) complexes containing the μ-oxo-di-μ-acetato motif
Source: Elsevier BV
Mechanism of intercalation into the DNA double helix by ethidium
Source: American Chemical Society (ACS)
A fluorescent complex between ethidium bromide and nucleic acids. Physical-chemical characterization.
Source: Elsevier BV
Ground spin state variability in manganese oxo aggregates. Demonstration of an S = 3/2 ground state for [Mn3O4(OH)(bpea)3](ClO4)3
Source: American Chemical Society (ACS)
Synthesis, antimicrobial screening, and DNA-binding/cleavage of new pyrazole-based binuclear CoII, NiII, CuII, and ZnII complexes
Source: Informa UK Limited
Binuclear copper and zinc complexes possessing bio-potential ligands: synthesis, characterization, antimicrobial, SOD mimetic, DNA binding, and cleavage studies
Source: Informa UK Limited
Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants.
Source: Elsevier BV
Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA
Source: American Chemical Society (ACS)
Spectroscopic investigation of differential binding modes of .DELTA.- and .LAMBDA.-Ru(bpy)2(ppz)2+ with calf thymus DNA
Source: American Chemical Society (ACS)
Pyrazolylborate−Zinc−Nucleobase-Complexes, 2:1 Preparations and Structures of TpCum,MeZn and TpPh,MeZn Complexes
Source: (:unav)
Design, synthesis, and DNA binding properties of bifunctional intercalators. Comparison of polymethylene and diphenyl ether chains connecting phenanthridine
Source: American Chemical Society (ACS)
Quenching of DNA-ethidium fluorescence by amsacrine and other antitumor agents: a possible electron-transfer effect
Source: American Chemical Society (ACS)
Synthesis, structure, protein binding, and cytotoxicity of zinc(II) complexes with tridentate NNO Schiff-base ligands
Source: Informa UK Limited
Synthesis, structure, and spectroscopic properties of copper(II) compounds containing nitrogen–sulphur donor ligands; the crystal and molecular structure of aqua[1,7-bis(N-methylbenzimidazol-2′-yl)-2,6-dithiaheptane]copper(II) perchlorate
Source: Royal Society of Chemistry (RSC)

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.