Synthesis, characterization, reactivity, and antifungal activity of chlorobis(2,4-dinitrophenoxo) monooxovanadium(V)

Abstract

[VOCl(OC₆H₃(NO₂)₂-2,4)₂] (1) has been synthesized by the reaction of VOCl₃ with bimolar amounts of Me₃SiOC₆H₃(NO₂)₂-2,4 in toluene and characterized by elemental analyses, molar conductance, infrared (IR), ¹H and ¹³C NMR and mass spectral, and thermal studies. Molecular modeling dynamics of the complex suggests tetrahedral geometry around vanadium. The reaction of 1 with sodium alkoxides, NaOR (OR = OMe (methoxy); OEt (ethoxy), OBuⁿ(n-butoxy); OPrⁱ (isopropoxy); and OAmⁱ(isoamyloxy)) afforded mixed alkoxo–phenoxo complexes, [VO(OR)(OC₆H₃(NO₂)₂-2,4)₂] authenticated by physicochemical and IR spectral studies. The antifungal activities of the ligand and complexes against three fungi, namely Aspergillus niger, Byssachlamys fulva, and Mucor circinelloides have been assayed by the minimum inhibitory concentration method. The complexes have improved antifungal activity compared to free ligand.

Keywords:

• 2,4-Dinitrophenol
• Monooxovanadium(V) complexes
• Sodium alkoxides
• Spectroscopic studies
• Antifungal activity

Acknowledgments

The authors thank Department of Science and Technology (DST), Government of India, New Delhi for providing financial assistance for FTIR Spectrometer facility to Chemistry Department under its FIST program. The authors also thank the Sophisticated Analytical Instrument Facility, Punjab University, Chandigarh, for recording ¹H and ¹³C NMR spectra and CDRI, Lucknow, India for mass spectra.