169
Views
25
CrossRef citations to date
0
Altmetric
Original Articles

Preparation and structural characterization of oxovanadium(V) complexes with Schiff bases and their inhibition studies on Helicobacter pylori urease

, , , , &
Pages 3510-3520 | Received 29 Jun 2011, Accepted 30 Aug 2011, Published online: 03 Oct 2011
 

Abstract

A series of structurally similar dinuclear oxovanadium(V) complexes, [VO2L]2 (L = L1 = 2-[(2-methylaminoethylimino)methyl]phenolate (1); L = L2 = 2-[(2-ethylaminoethylimino)methyl]phenolate (2); L = L3 = 2-[(2-isopropylaminoethylimino)methyl]phenolate (3)), has been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The V in each complex is octahedral, with three donors of L and one oxo defining the equatorial plane, and with two oxos occupying the axial positions. The complexes were tested for their urease inhibitory activities. The inhibition rate (%) of 1, 2, and 3 at 100 µmol L−1 on urease are 67 ± 1, 53.5 ± 0.9, and 44 ± 1. The relationship between structures of the complexes and the urease inhibitory activities indicates that shorter terminal groups of the complexes have stronger activities against urease. Molecular docking study of the complexes with the Helicobacter pylori urease was performed.

Acknowledgments

This work was financially supported by the National Science Foundation of China (Project No. 20901036).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.