Synthesis, characterization, and antibacterial activity of organotin(IV) complexes with 2-hydroxyacetophenone thiocarbohydrazone

Abstract

Six new organotin(IV) complexes were synthesized by direct reaction of RSnCl₃ (R = Me, Bu and Ph) or R₂SnCl₂ (R = Me, Bu and Ph) and 2-hydroxyacetophenone thiocarbohydrazone [H₂APTC] under purified nitrogen in the presence of base in 1 : 2 : 1 molar ratio (metal: base: ligand). Complexes 2–7 have been characterized by elemental analyses, molar conductivity, UV-Visible, IR and ¹H NMR spectral studies. Complexes 2–7 are non-electrolytes. The molecular structure of [Me₂Sn(APTC)] · (C₂H₅OH) (5) has been determined by X-ray diffraction analysis. The thiocarbohydrazone ligand (1) and 2–7 have been tested for antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi and Enterococci aeruginosa.

Keywords:

• Organotin(IV) complexes
• Thiocarbohydrazone ligand
• Spectral analyses
• Crystal structure
• Antibacterial activity

Acknowledgments

The authors would like to thank Ministry of Science, Technology and Innovation (MOSTI) and Universiti Malaysia Sarawak (UNIMAS) for the financial support (Grant No. 06-01-09-SF0046). The authors would also like to thank Prof Ismail Ahmad from the Department of Molecular Biology UNIMAS for the antibacterial test.