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Journal of Coordination Chemistry Volume 64, 2011 - Issue 22
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Original Articles

Mixed-ligand manganese(II)-phenolate complexes: study of DNA cleavage, cytotoxic activity, and induction of apoptosis

En-Jun Gao Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, ChinaCorrespondence[email protected]
,
Ying Zhang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Lin Lin Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Ren-Shu Wang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Lei Dai Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Qi Liang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Ming-Chang Zhu Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Mei-Lin Wang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Lei Liu Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
,
Wen-Xuan He Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
&
Yan-Jin Zhang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang 110142, China
 show all
Pages 3992-4005 | Received 21 Aug 2011, Accepted 14 Oct 2011, Published online: 11 Nov 2011
 
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Abstract

Two manganese complexes, [Mn(L1)2(dibe)2](L1) (1) and [Mn(L2)2(dibe)2] (2) (where L1 = 2,2′-bipyridine (bipy), L2 = 1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe = 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells.

Acknowledgements

We gratefully acknowledge the Natural Science Foundation of China (No. 20971090, 21171118), the science and technology projects fund of Shenyang City (No. F10-215-1-00).

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