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Journal of Coordination Chemistry Volume 65, 2012 - Issue 1
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Original Articles

Synthesis and solution structures of some platinum(II) complexes containing chelating safrole and amine

Tran Thi Da Department of Chemistry, Hanoi National University of Education, 136 Xuanthuy Street, Caugiay, Hanoi, VietnamCorrespondence[email protected]
,
Le Xuan Chien Department of Chemistry, Hanoi National University of Education, 136 Xuanthuy Street, Caugiay, Hanoi, Vietnam
,
Nguyen Thi Thanh Chi Department of Chemistry, Hanoi National University of Education, 136 Xuanthuy Street, Caugiay, Hanoi, Vietnam
,
Le Thi Hong Hai Department of Chemistry, Hanoi National University of Education, 136 Xuanthuy Street, Caugiay, Hanoi, Vietnam
&
Nguyen Huu Dinh Department of Chemistry, Hanoi National University of Education, 136 Xuanthuy Street, Caugiay, Hanoi, Vietnam
Pages 131-142 | Received 25 Aug 2011, Accepted 24 Oct 2011, Published online: 14 Dec 2011
 
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Abstract

Reaction of the dinuclear chelate ring complex [Pt2Cl2(Saf-1H)2], Saf-1H: deprotonated safrole, with various amines afforded cis-[Pt(Saf-1H)(Am)Cl], Am: NH3 (1), Me2NH (2), Et2NH (3), morpholine (4), cyclohexylamine (5), benzylamine (6), aniline (7), o-toluidine (8), m-toluidine (9), p-toluidine (10), pyridine (11), 2-aminopyridine (12), and quinoline (13). The 1H NMR and nuclear overhauser effect spectroscopy (NOESY) spectra of the reported complexes were accurately analyzed. NOESY spectra show that the complexes have a cis-configuration, in which the alkyl and aryl groups of coordinated amines are in proximity to the allyl group of chelating safrole. Complexes 11, 12, and 13 exhibit inhibitory activities on human cancer cells HepG2 and Lu with IC50 = 2.5–5.0 µg mL−1.

Acknowledgments

This work was supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED).

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