Abstract
Three ferrocenyl amides have been synthesized and characterized by analytical techniques. Based on single-crystal X-ray analysis, a supramolecular structure was attributed to 1 owing to the presence of intermolecular non-covalent interactions. UV-Visible spectroscopy, viscometry, and dynamic laser light scattering was used to assess the mode of interaction and binding of these complexes with DNA, which varied in the sequence 1 > 2 > 3. The binding is presumably due to the ability of these complexes to form secondary non-covalent interactions with DNA bases. Complex-DNA adduct formation depends on the nature of R of the amide.
Acknowledgments
We are grateful to Higher Education Commission and Quaid-i-Azam University, Islamabad, Pakistan for financial support.
Notes
These two authors contributed equally.
These two authors contributed equally.