Synthesis, crystal structure, and DNA interaction of an oxovanadium(IV) complex containing L-valine Schiff base and 1,10-phenanthroline

Abstract

A new oxovanadium(IV) complex, [VO(sal-val)(phen)]CH₃OHH₂O (sal-val = Schiff base derived from salicylaldehyde and L-valine, phen = 1,10-phenanthroline), has been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. This crystal belongs to monoclinic crystal system, C2/c space group with crystallographic data: a = 28.031(4) Å, b = 9.342(3) Å, c = 19.198(4) Å, β = 99.425(2)°, and Z = 8. The V^IV was six-coordinate to form an octahedral geometry. In the crystal, intermolecular hydrogen bonding and π–π stacking formed the 1-D network. DNA-binding properties of this oxovanadium(IV) complex with calf-thymus DNA (CT-DNA) were investigated using UV, fluorescence, and circular dichroism spectra. The complex can bind to CT-DNA via intercalation.

Keywords:

• Oxovanadium(IV) complex
• L-valine
• Schiff base
• DNA interaction

Acknowledgements

This project was supported by the Natural Science Foundation of Shandong Province of China (No. Y2004B02) and the Shandong Tai-Shan Scholar Research Found.