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Journal of Coordination Chemistry Volume 66, 2013 - Issue 5
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Original Articles

Structural and biological studies of new monomeric, tetrameric, and polymeric organotin(IV) esters of 3-(benzo[d][1,3]dioxol-4-yl)propanoic acid

Mukhtiar Hussain Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, PakistanCorrespondence[email protected]
,
Zia-Ur-Rehman Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
,
Muhammad Sheeraz Ahmad Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
,
Muhammad Altaf Institute of Physics, University of Neuchátel, Rue Emile-Argand 11, CH-2009, Neuchátel, Switzerland
,
Helen Stoeckli-Evans Institute of Physics, University of Neuchátel, Rue Emile-Argand 11, CH-2009, Neuchátel, Switzerland
&
Saqib Ali Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Pages 868-860 | Received 16 Jun 2012, Accepted 29 Nov 2012, Published online: 15 Mar 2013
 
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Abstract

Six new monomeric, tetrameric, and polymeric organotin(IV) derivatives of sodium 3-(benzo[d][1,3]dioxol-4-yl)propanoate (NaL) have been synthesized and characterized by various analytical techniques. These compounds show different structural behavior in solution and solid state as confirmed by NMR and X-ray single-crystal analysis. Antimicrobial and antitumor activities are mainly governed by diffusion, lipophilicity, geometry, and steric factors. The high antitumor and antifungal activities of some of these organotin compounds demand further investigations to commercialize them as new tin-based drugs.

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