Two metal-pipemidic acid complexes modifying Keggin polyoxometalates

Abstract

Two new organic–inorganic hybrid compounds based on Keggin polyoxometalates (POMs) and the quinolone antibacterial, pipemidic acid (HPPA), {[Cu(PPA)₂]₂[H₃PMo₁₂O₄₀]}·8H₂O (1), and {[Zn(PPA)₂][H₃PMo₁₂O₄₀]}·[HPPA]·3H₂O (2) have been synthesized under hydrothermal conditions and structurally characterized. In 1, Keggin POMs combine with two chelate Cu(PPA)₂ complexes forming a discrete “seesaw-like” motif, while Keggin POMs combine with the binuclear zinc clusters [Zn₂(PPA)₄] forming a discrete “dumbbell-like” motif in 2. Antitumor activities in vitro and the interactions with CT-DNA of the compounds have been investigated by MTT experiment and UV spectra, respectively.

Keywords:

• Polyoxometalate
• Pipemidic acid
• Antitumor activity
• Interaction with CT-DNA

Acknowledgments

This work is financially supported by the National Natural Science Foundation (Grant Nos. 20901031 and 21271089) and Scientific and technological innovation team (2012TD010) and Scientific and technological project (GC09C317), and Postdoctoral Foundation of Heilongjiang Province.