Synthesis, characterization, semi-empirical study and biological activities of homobimetallic complexes of tranexamic acid with organotin(IV)

Abstract

The Schiff base has been synthesized by reacting tranexamic acid with indol-3-carboxyaldehyde in the first step and then with carbon disulfide at room temperature in the second step. The homobimetallic complexes have been synthesized by reaction of Schiff base with R₂SnCl₂ and R₃SnCl in 1 : 2 M ratio under stirring, where R = methyl, n-butyl and phenyl. The ligand and complexes have been characterized by elemental analysis, FT-IR, multinuclear NMR (¹H, ¹³C and ¹¹⁹Sn) and semi-empirical study. IR data reveal the bidentate nature of the ligand. Five- or six-coordinate geometry was confirmed in solution by NMR spectroscopy. The homobimetallic complexes and ligand were tested in vitro against some pathogenic bacteria and fungi to assess their antimicrobial properties. The complexes show biological activities with few exceptions.

Keywords:

• Tranexamic acid
• Indol-3-carboxyaldehyde
• Organotin(IV)
• FT-IR
• NMR
• Semi-empirical study
• Biological activity

Acknowledgments

Quaid-i-Azam University, Islamabad is acknowledged for financial support as URF and Pakistan Science Foundation is acknowledged for partial support under the project No. PSF/Res/P-GCU/Chem(436).