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Journal of Coordination Chemistry Volume 66, 2013 - Issue 11
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Syntheses, characterizations and bioactivities on HeLa cells and KB cells of two dinuclear manganese complexes with carboxylate bridges

En-Jun Gao Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang, ChinaCorrespondence[email protected]
,
Lin Lin Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang, China
,
Bo Wang Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang, China
,
Ming-Chang Zhu Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang, China
,
Wei Jiao Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang, China
&
Ting-Li Liu Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang, China
Pages 1945-1958 | Received 22 Dec 2011, Accepted 17 Jan 2013, Published online: 10 May 2013
 
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Abstract

To explore anti-tumor activities of manganese complexes, two complexes have been synthesized and characterized. Complex 1 is bridged by 1,10-phenanthroline and 2,4-biphenyl dicarboxylate. The two complexes have strong fluorescent emission and interact with DNA in an intercalative mode. The complexes also exhibit significant cytotoxic specificity and cancer cell inhibition.

Acknowledgements

We gratefully acknowledge the Natural Science Foundation of China (No. 20971090, 21171118), the Distinguished Professor Project of Liaoning province and the science and technology special fund of Shenyang City (Nos. F10-215-1-00 and F12-151-9-00).

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