Abstract
A Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its yttrium(III) (Y(III))complex, Y2L2(NO3)2·2H2O, have been synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Y(III) complex has been determined by single-crystal X-ray diffraction, revealing a centrosymmetric binuclear neutral entity where Y(III) centers are bridged by two phenoxo oxygens. The DNA-binding properties of the Schiff base H2L and the Y(III) complex were investigated by spectrophotometric methods and viscosity measurements. The results suggest that ligand H2L and Y(III) complex both bind to DNA via groove binding, and the Y(III) complex binds to DNA more strongly than H2L. The antioxidant activity of the Y(III) complex was determined by superoxide and hydroxyl radical-scavenging method in vitro, which indicates that Y(III) complex scavenges OH· and O2−· radicals.
Supplementary material
Crystallographic data (excluding structure factors) for the structure reported in this paper have been deposited with the Cambridge Crystallographic Data Center with reference number CCDC 917806. Copies of the data can be obtained, free of charge, on application to the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK. Tel: +44 01223 762910; Fax: +44 01223 336033; E-mail: [email protected] or http://www.ccdc.cam.ac.uk.
Acknowledgments
The authors acknowledge the financial support and grant from ‘Qing Lan’ Talent Engineering Funds by Lanzhou Jiaotong University. This work is also supported by the Fundamental Research Funds for the Gansu Province Universities (212086).