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Abstract
By introducing antibacterial drug pipemidic acid into octamolybdates, two new compounds, (HPPA)4[Mo8O26] 2H2O (1) and [Ni2(PPA)2(H2O)4] [Mo8O26] 3H2O (2) (PPA = 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid), have been synthesized and characterized by physical methods. Single-crystal X-ray analysis reveal that 1 and 2 crystallize in the triclinic system, space group P-1, in which supramolecular interactions play vital roles in stabilizing the structure of 1 and 2. The results of their antitumor activities in vitro show that the compounds exhibit good anti-SGC7901 and anti-SMMC7721 activities, which indicates that the antitumor activities of Polyoxometalates can be modulated by the surface modification with drugs.
Acknowledgments
This work was financially supported by the the training program for New Century Excellent Talents in universities (1253-NCET-022) in Heilongjiang Province.
