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Abstract
Pd(II) complexes with imidazole linked to dithiocarbamate derivatives were synthesized by reacting 1-(alkyldithiocarbonyl)-imidazoles with PdCl2 in a 2 : 1 molar ratio. The complexes were characterized by elemental analyses, FT-IR, and 1H NMR. The single crystal structure of 4 shows that the ligand is chelated by nitrogens in imidazole, instead of sulfur, to palladium. All synthesized compounds were tested for in vitro anticancer activities. Compound 5 had better activities in the HL-60 cell line and twofold better activities in the HeLa cell line than that of cisplatin.
Graphical Abstract
Funding
We thank the financial support of the National Natural Science Foundation of China [grant number 31201567]. The research was also supported by the CAS/SAFEA International Partnership Program for Creative Research Teams.
