Synthesis, physicochemical characterization, and biological activity of nanocomplexes of iron(III) of 3(2′-hydroxyphenyl)-5-(4-substituted phenyl) pyrazolines and dithiophosphoric acid

Abstract

Complexes of iron(III) with dithiophosphoric acid and 3(2′-hydroxy phenyl)-5-(4-substituted phenyl) pyrazolines, [Fe(C₆O₁₄O₂PS₂)₂(C₁₅H₁₂N₂OX)], and [Fe(C₆O₁₄O₂PS₂)(C₁₅H₁₂N₂OX)₂], where (C₆O₁₄O₂PS₂H) = dithiophosphoric acid, (C₁₅H₁₃N₂OX) = deprotonated 3(2′-hydroxy phenyl)-5-(4-substituted phenyl)pyrazolines (X = H, CH₃, OCH₃, Cl), have been synthesized. These complexes have been physicochemically characterized by elemental analysis (C, H, N, S, Cl, and Fe), magnetic moment data, thermogravimetric analysis, molar conductance, cyclic voltammetry, and spectral analysis (UV–visible, IR, and Fast atom bombardment mass spectrometry). Scanning electron microscopy, TEM, and PXRD have been carried out for powdered samples, which show nanometric particles of these derivatives. Antibacterial and antifungal potential of free pyrazoline and iron(III) complexes have been evaluated.

Graphical Abstract

Keywords:

• Iron(III)
• Pyrazolinates
• Dithiophosphates
• Particle size
• Antimicrobial activity

Acknowledgements

The authors are thankful to SAIF, CDRI, Lucknow (India), Punjab University, Chandigarh; Delhi University, IIT Delhi and BHU, Varanasi (India) and Department of Chemistry, DDU Gorakhpur University for providing the necessary spectral and analytical data.