Synthesis, characterization, equilibria and biological activity of dimethyltin(IV) complex with 1,4-piperazine

Abstract

The interaction of dimethyltin(IV) dichloride (DMT) with 1,4-piperazine (PIP) was investigated. The complex formation equilibria of the complexes formed in solution were investigated. The stoichiometry and stability constants of the complexes formed in solution phase were determined at different temperatures and in solutions of dioxane–water mixtures of different dielectric constants. The equilibrium constant for the displacement of piperazine coordinated to dimethyltin(IV) by inosine as a representative of DNA was calculated. (DMT)(PIP)·3H₂O was synthesized and characterized by elemental analysis, spectral, and thermal techniques. The antitumor activity of the complex was screened.

Keywords:

• Organotin(IV) complexes
• 1,4-Piperazine
• Equilibrium constants
• Effect of temperature
• Effect of solvent
• Antitumor activity