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Abstract
Three Ru complexes coordinated by oxfloxacin, [Ru(L)2(OFX)]Cl·2H2O (L = bpy, 1; dmbpy, 2; phen, 3; and OFX = ofloxacin), were synthesized and characterized. These complexes can inhibit the growth of cervical cancer HeLa cells efficiently. Furthermore, these three complexes exhibited excellent binding affinities with DNA, as confirmed by spectroscopy methods and viscosity experiments. Therefore, the synthesized Ru(II) complexes have excellent DNA-binding abilities with potential applications in cancer chemotherapy.
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Funding
This work was supported by the Science and Technology Item Foundation of Guangzhou [grant number 2013J4100072]; the Joint Natural Sciences Fund of the Department of Science and Technology and the First Affiliated Hospital of Guangdong Pharmaceutical University [grant number GYFYLH201309].