Synthesis, structure, and urease inhibitory activities of Co(III), Mn(II) and Zn(II) complexes with hydrazone derived from protocatechuic acid

Abstract

[Co^III(L₁)₂·H₂O]NO₃ (1), [Mn^II(L₁)₂·H₂O] (2), and [Zn^II(L₁)₂·H₂O] (3) with a hydrazone derived from protocatechuic acid (HL₁ = C₁₅H₁₃N₃O₃) were designed, synthesized, and characterized by C, H, N elemental analyses, single-crystal X-ray diffraction, and IR spectra, which revealed that the three complexes are similar structures. Docking study has been done. The urease inhibitory activities of the three complexes were tested. Complexes 1 and 3 showed strong inhibitory activity against jack bean urease with IC₅₀ values of 45.9 and 11.64 μM. Complex 2 had no obvious inhibitory activity to urease; the IC₅₀ was > 50 μM.

Keywords:

• Complex
• hydrazone
• urease inhibitors
• protocatechuic acid
• molecular docking

Acknowledgements

We thank the financial support from National Natural Science Foundation of China (Grant No. 31200090), Scientific Research Foundation for Returned Scholars, Ministry of Education of China, and National College Students’ Innovative and Entrepreneurial Training Plan of China (Grant No. 201410433033).