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Journal of Coordination Chemistry Volume 70, 2017 - Issue 20
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Syntheses, crystal structures, and Jack bean urease inhibitory activities of copper(II) complexes derived from 4-tert-butyl-N′-(1-(pyridin-2-yl)ethylidene)benzohydrazide

Sihan GuoDepartment of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, P. R. China
,
Tianrui WangSchool of Life Sciences, Shandong University of Technology, Zibo, P. R. China
,
Jiajin XinSchool of Life Sciences, Shandong University of Technology, Zibo, P. R. China
,
Qiqige HuDepartment of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, P. R. China
,
Shanfa RenSchool of Life Sciences, Shandong University of Technology, Zibo, P. R. China
,
Guihua ShengSchool of Life Sciences, Shandong University of Technology, Zibo, P. R. China
,
Lin PanDepartment of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, P. R. China
,
Chenglu ZhangDepartment of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, P. R. China
,
Kun LiDepartment of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, P. R. China
&
Zhonglu YouDepartment of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, P. R. ChinaCorrespondence[email protected]
 show all
Pages 3449-3458 | Received 25 May 2017, Accepted 08 Sep 2017, Published online: 20 Oct 2017
 
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Abstract

Two new copper(II) complexes, [CuL(HL)]·ClO4 (1) and [Cu2Br2L2]·0.85H2O (2), where L is the monoanionic form of 4-tert-butyl-N′-(1-(pyridin-2-yl)ethylidene)benzohydrazide (HL), have been prepared. The complexes were characterized by infrared and UV–vis spectra, and single crystal X-ray diffraction. Complex 1 is a mononuclear copper(II) species and 2 is a bromido-bridged dinuclear copper(II) species. The Cu ion in 1 is in an octahedral coordination mode and that in 2 is trigonal-bipyramidal. The Jack bean urease inhibitory assay indicated that 2 is active, with IC50 value of 20.6 ± 2.3 μmol L−1, while 1 is inactive. Molecular docking of 2 with Jack bean urease was studied.

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