Abstract
A series of oxidovanadium(V) complexes, [VOLa-cL′] (L′ = ethyl maltolate), were synthesized by reaction of VOSO4 with the aroylhydrazones 2-amino-N'-(2-hydroxybenzylidene)benzohydrazide (H2La), N'-(3-bromo-2-hydroxybenzylidene)-3-hydroxylbenzohydrazide (H2Lb) and N′-(2-hydroxy-5-nitrobenzylidene) pivalohydrazide (H2Lc), respectively. The complexes were characterized by physico-chemical methods. Molecular structures of the complexes were further characterized by single crystal X-ray diffraction. The V ions in the three complexes are coordinated by three donor atoms of the aroylhydrazone ligands, two donor atoms of the ethyl maltolate ligand, and one oxo group. Biological study of the complexes indicates that they are insulin-like agents, which stimulated glucose utilization in a dose dependent manner over the concentration range 125 μM to 1 mM.
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Acknowledgements
We gratefully acknowledge the financial support by the Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region (NJZY19220 and NJZY19223), Inner Mongolia Key Laboratory of Photoelectric Functional Materials, Chifeng University Key Laboratory of Photoelectric Functional Materials, and Chifeng University Science and Research Creative Team.
Disclosure statement
No potential conflict of interest was reported by the authors.