Synthesis, solution stability, and structural characterization of quinolinol-based silver(I) complexes

Abstract

Three silver(I) complex compounds of halogen derivatives of 8-quinolinol (XQ), [Ag(HdClQ)₂](NO₃)·CH₃OH (1), [Ag(HdBrQ)₂](NO₃) (2), and [Ag(BrQ)]_n (3) (HdClQ = 5,7-dichloro-8-quinolinol, HdBrQ = 5,7-dibromo-8-quinolinol, and HBrQ = 7-bromo-8-quinolinol), have been prepared with the aim to study their anticancer properties. All compounds were characterized by IR and NMR spectroscopy and elemental analysis. Single-crystal X-ray diffraction analysis revealed that crystal structure of 1 is ionic, 2 is molecular while 3 is polymeric. All three XQ ligands in 1–3 are N,O-chelate coordinated to the Ag(I) central atoms which are in a deformed square planar (1), distorted tetragonal pyramidal (2), or distorted triangular arrangement (3). Stability of all compounds in DMSO was proved by ¹H NMR and UV-vis spectroscopy. Biological activity has not been studied because of limited solubility of prepared compounds in DMSO/water mixture.

Graphical Abstract

Keywords:

• 5,7-Dichloro-8-quinolinol
• 5,7-dibromo-8-quinolinol
• 7-bromo-8-quinolinol
• silver complexes
• structure

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The financial supports of Slovak grant agencies Vedecká Grantová Agentúra MŠVVaŠ SR a SAV (1/0148/19) and Agentúra na Podporu Výskumu a Vývoja (APVV-18-0016), as well as P.J. Šafárik University in Košice (VVGS-PF-2019-1051), are gratefully acknowledged. The crystallographic measurements used instruments of the ASTRA lab established within the Operation program Prague Competitiveness – project CZ.2.16/3.1.00/24510.