Synthesis and anticancer property of an octanuclear Mn(III) compound based on pyrazole bifunctional ligand

Hongliang XuSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, P.R. China; ;Jiangsu Laboratory of Advanced Functional Material, Department of Materials Engineering, Changshu Institute of Technology, Changshu, Jiangsu, P.R. ChinaView further author information

Xinchen LiJiangsu Laboratory of Advanced Functional Material, Department of Materials Engineering, Changshu Institute of Technology, Changshu, Jiangsu, P.R. ChinaView further author information

Xujing ZhangSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, P.R. China; View further author information

Long PengSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, P.R. China; View further author information

Dengfeng ZouSchool of Pharmacy, Guilin Medical University, Guilin, Guangxi, P.R. China; Correspondence[email protected] [email protected]
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Jie YangJiangsu Laboratory of Advanced Functional Material, Department of Materials Engineering, Changshu Institute of Technology, Changshu, Jiangsu, P.R. ChinaCorrespondence[email protected] [email protected]
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Abstract

Herein, an octanuclear complex [Mn₈(μ₄-O)₄(phpy)₈(MeOH)₄]·MeOH·H₂O based on 5-(2-hydroxyphenyl)-3-pyrazole (HphpyH) has been successfully synthesized and characterized. The compound can self-assemble to form nanoparticles (NPs) by nanoprecipitation with PEG_-5000. [Mn₈(μ₄-O)₄(phpy)₈(MeOH)₄]·MeOH·H₂O NPs have a low IC₅₀ (half maximal inhibitory concentration) of only 44 μg/mL (2.3 μM) on HeLa cells. The results show that [Mn₈(μ₄-O)₄(phpy)₈(MeOH)₄]·MeOH·H₂O NPs are able to inhibit cell proliferation and migration in vitro.

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The authors acknowledge financial support from the Natural Science Foundation of China (Grant No. 81460119), National Natural Science Foundation of Jiangsu Province (Grant No. BK2012210), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grant No. 10KJB430001) and the Opening Fund of Jiangsu Key.

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Synthesis and anticancer property of an octanuclear Mn(III) compound based on pyrazole bifunctional ligand

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Synthesis and anticancer property of an octanuclear Mn(III) compound based on pyrazole bifunctional ligand

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