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Abstract
In this work, 5,5′-carbonyldiisophthalic acid (H4cipa) was used as a ligand to react with Zn(NO3)2·6H2O in a mixed solvent of DMF and water to prepare a new metal-organic framework (MOF) with the chemical formula of [Zn2(cipa)(H2O)2](DMF) (1). Due to its O donor sites within the one-dimensional channels and high density of open metal sites, the activated 1a was applied as a heterogeneous catalyst for the formation of C–C bonds of carbonyl compounds in the absence of solvents, which shows high efficiency and size-selectivity. Furthermore, the possible reaction mechanism has been proposed based on the experimental results. The treatment activity of the new compound on the Mg63 osteosarcoma cell line was evaluated and the possible mechanism was discussed. First, flow cytometry was performed to detect the levels of the Mg63 cancer cells’ autophagy levels after indicated compound treatment. Next, real time RT-PCR assay was further conducted to measure the relative expression levels of the autophagic genes under treatment.
Graphical abstract
Acknowledgements
The research did not receive any specific funding.
Disclosure statement
The authors declare there is no conflict of interest regarding the publication of this paper.
Data availability
The data used to support the findings of this study are included within the article.