Bio-medical potential of chalcone derivatives and their metal complexes as antidiabetic agents: a review

Abstract

In nature, chalcones are extensively available in edible plants and as starting components of flavonoids. Based on the presence of reactive bi-electrophilic group and the keto-vinyl spacer, chalcones and their metal complexes possess significant therapeutic potential against many enzymes. Proper substitution with functional groups enables it to interact with enzymes in a competitive or non-competitive way. In this review, interaction mechanisms of chalcone with the enzymes involved in diabetes and therapeutic potential of its metal complexes is reviewed. Chalcones and their metal complexes possess promising activity against α-amylase, α-glucosidase, aldose reductase, and tyrosine phosphatase enzymes and have other biological activities.

Graphical Abstract

Keywords:

• Chalcone
• diabetes
• tyrosine phosphatase
• α-amylase
• α-glucosidase
• aldose reductase
• metal complexes

Disclosure statement

The authors state no conflict of interest.

Data availability statement

The data confirming the study is obtainable from the corresponding author upon request.