A centipede like thiocyanate-bridged muti-nuclear copper(I/II) complex derived from 2-(((2-(dimethylamino)ethyl)imino)methyl)-5-fluorophenol with urease inhibitory activity

Abstract

A centipede like thiocyanate-bridged multi-nuclear copper(I/II) complex, [Cu₂L(CH₃OH)(NCS)₃]_n, derived from 2-(((2-(dimethylamino)ethyl)imino)methyl)-5-fluorophenol (HL), was prepared and characterized by elemental analysis, IR and UV–vis spectra, as well as single crystal X-ray diffraction. The Cu1 ion in the +2 oxidation state is coordinated by the tridentate Schiff base ligand in a square pyramidal geometry, with the other two sites occupied by one N atom of the thiocyanate ligand and one methanol O atom. The Cu2 ion in the +1 oxidation state is coordinated by one N and three S atoms from four thiocyanate ligands, forming a tetrahedral geometry. The CuI ions are linked by thiocyanate ligands to form a one-dimensional chain with [Cu^I₂(μ_1,3,3-NCS)₂] as the repeat unit. The [Cu^IIL(CH₃OH)] moieties are linked to the chain through thiocyanate ligands. The complex has remarkable inhibitory activity on Jack bean urease with an IC50 value of 1.3 μmol L^–1.

Graphical Abstract

Keywords:

• Schiff base
• copper(I/II) complex
• thiocyanate
• crystal structure
• urease inhibition

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the high level scientific research achievement funding program of Liaoning Normal University (grant number 21GDL003).