Synthesis, crystal structures and DNA-binding properties of Zn(II), Cd(II), Mn(II), Cu(II) complexes based on a thiazole derivative and carboxylic acids

Abstract

By single-crystal X-ray diffraction (XRD) analysis, five complexes, catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)-1,3-benzothiazole)-aqua-zinc(II)] (1), catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-cadmium(II)] (2), catena-[hepta(µ-2,2-bis(4carboxyphenyl)hexafluoropropane)-diaqua-bis(2-(pyidin-2-yl)-1,3-benzothiazole)-tri-manganes(II)] (3), catena-[(µ-benzene-1,2,4,5-tetracarboxylato)-(2-(pyidin-2-yl)-1,3benzothiazole)copper(II)] (4) and catena-[(µ-3-nitrobenzene-1,2-dicarboxylato)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-zinc(II)] (5), were characterized in this research. In these five complexes, H₂hfipbb = 2,2-bis(4-carboxyphenyl)hexafluoropropane, H₄btec = 1,2,4,5-benzenetetracarboxylic acid, H₂NPTA = 3-nitrophthalic acid and bpt = 2-(pyridin-2-yl)benzo[d]thiazole). Complexes 1 and 2 occur in the monoclinic system with space group C2/c, 4 and 5 occur in the monoclinic system with space group P2₁/c, and 3 occurs in the triclinic system with space group P-1. The interaction between CT-DNA (calf thymus DNA) and those complexes was examined using UV spectroscopic analysis, fluorescent spectroscopic analysis, circular dichroism spectroscopy (CD) and viscosity analysis. This research reveals that those complexes have strong ability to interact with DNA, and they all bind to DNA in an intercalation mode, thus affecting the structure of DNA. This binding mode can arise from the interaction between the benzothiazole metal complexes and DNA. Hence, we hope to provide some scientific research bases for studying benzothiazole complexes and designing new thiazole anticancer drugs.

GRAPHICAL ABSTRACT

Keywords:

• 2-(Pyridin-2-yl)benzo[d]thiazole
• complex synthesis
• spectrometric method
• CT-DNA binding
• intercalative binding

Disclosure statement

We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service or company that could be construed as influencing the position presented in, or the review of the manuscript entitled “Synthesis, crystal structures and DNA-binding properties of Zn(II), Cd(II), Mn(II), Cu(II) complexes based on a thiazole derivative and carboxylic acids”.