Abstract
Five copper(II), zinc(II) and nickel(II) complexes, [Cu2L2(μ 1,1-N3)2] (1), [Zn2L2(μ 2-η 1:η 1-CH3COO)(NCS)]EtOH (2), [Zn2L2(μ 2-η 1:η 1-CH3COO)(N3)]MeOH (3), [Zn2Cl2L2] (4) and [NiL(HL)]ClO4 (5), were prepared from the Schiff base 3-methyl-2-((pyridin-2-ylmethylene)amino)phenol (HL). The compounds have been characterized by physico-chemical methods including elemental analysis, IR, and UV–Vis spectra. Structures of the five new complexes were determined by single crystal X-ray diffraction. The copper ions in 1 are in square pyramidal, while zinc ions in 2, 3, and 4 are distorted square pyramidal, and the nickel ions in 5 are octahedral. The biological assay indicated that zinc complex 2 has the most effective activity on Jack bean urease with IC50 = 1.7 ± 0.8 μmol·L−1. Molecular docking was performed to study the interaction between the active center of the urease with molecules of the complexes.
Disclosure statement
No potential conflict of interest was reported by the author(s).