Cu(II) coordination polymers based on 1,3,5-tris(triazol-1-ylmethyl)-2,4,6-trimethylbenzene: synthesis, structure, and biological properties

Abstract

Two new Cu(II)-based coordination polymers, [Cu(TTTMB)(Hbtrc²⁻)]_n (1) and {[Cu(TTTMB)₂(H₂O)₂](NO₃)₂(H₂O)₄}_n (2), were synthesized under hydrothermal conditions (TTTMB = 1,3,5-tris(triazol-1-ylmethyl)-2,4,6-trimethylbenzene; H₃btrc = 1,3,5-trimesic acid). The structures of these polymers were established by elemental analysis, IR, and single-crystal X-ray diffraction analysis. Polymer 1 displays a three-dimensional (3-D) structure with the Schläfli symbol (4·6²)(4·6⁷·8²) and crystallizes in the monoclinic space group P2(1)/n. Each Cu(II) in 1 is five-coordinate in a slightly distorted rectangular pyramid geometry. Polymer 2 has a 2-D network structure with (4,4) topology and each Cu(II) ion has a slightly distorted octahedral coordination geometry. The antidiabetic activity against α-amylase and antioxidant activity against DPPH of the two Cu(II)-based complexes were evaluated in vitro. Polymers 1 (IC₅₀ = 1.43 mg/mL) and 2 (IC₅₀ = 2.45 mg/mL) exhibited more effective inhibition on α-amylase than the standard drug acarbose (IC₅₀ = 2.94 mg/mL). The results of the antioxidant studies revealed that 2 demonstrated a potent scavenging effect on DPPH with IC₅₀ values of 2.59 mg/mL, slightly lower than that of vitamin E (2.67 mg/mL).

KEYWORDS:

• Cu(II) Coordination polymer
• crystal structure
• α-amylase inhibition
• antioxidant activity

Acknowledgments

The authors are grateful to Zhongyuan University of Technology (Grant Nos. K2021YY009 and 202210465105) and Laboratory Work Research Association of Universities in Henan Province (Grant No. ULAHN202115) for financial support.

Disclosure statement

All authors declare that there is no conflict of interest in this study.

Additional information

Funding

This work was supported by Zhongyuan University of Technology (Grant Nos. K2021YY009 and 202210465105) and Laboratory Work Research Association of Universities in Henan Province (Grant No. ULAHN202115).