Synthesis, characterization, and anticancer activity of some mononuclear ruthenium(II) compounds

Abstract

Mononuclear Ru-based compounds cis-Ru^II(dppm)₂Cl₂ (1) and trans-Ru^II(dppe)₂Cl₂ (4) were synthesized by treatment of Ru^IICl₂(DMSO)₄ with dppm or dppe, respectively (dppm = bis(diphenylphosphino) methane, dppe = 1,2-bis(diphenylphosphino) ethane, DMSO = dimethyl sulfoxide). Mononuclear Ru-based compounds trans-Ru^II(dppm)₂Cl₂ (2) and cis-Ru^II(dppe)₂Cl₂ (3) were obtained by reaction of Ru^IICl₂(PPh₃)₃ with dppm or dppe, separately. These two pair of cis–trans isomers, cis/trans-Ru^II(dppm)₂Cl₂ and cis/trans-Ru^II(dppe)₂Cl₂, were characterized by electronic absorption spectra, infrared, elemental analysis, ¹H NMR, ¹³C NMR, ³¹P NMR, and single-crystal X-ray diffraction analysis. Both the crystal structure data and electronic absorption spectra indicate that the cis-isomer is a more thermodynamically stable structure and has lower energy than the trans-isomer. The luminescence spectroscopic study and relative cell viability of 1–4 on HeLa cancer cells has been investigated.

KEYWORDS:

• Ruthenium
• anticancer
• diphosphine ligand
• crystal structure
• electronic absorption spectra

Disclosure statement

The author declares that there is no conflict of interests regarding the publication of this article.

Additional information

Funding

We thank the Supported by Hubei Provincial Natural Science Foundation of China (No. 2022CFB532).