ALTERATIONS OF MALE WISTAR RAT JEJUNUM INDUCED BY DODINE (n-DODECYLGUANIDINE ACETATE)

Abstract

The effect of Dodine on the intestine was studied after a single administration of 1000 mg/kg, which corresponds to the LD50 in male Wistar rats. At this dose, a significant decrease in body weight was observed, accompanied by diarrhea, which may be associated with intestinal alterations. The chemical induced a significant reduction of the protein con tent and in sucrase activity in the jejunum. Morphological alterations included a significant decrease in crypt height and in villus length and depth. The intestinal modifications observed in animals after Dodine administration may explain the observed loss in body weight and diarrhea.

Additional information

Notes on contributors

M. P. Vinardell

Address correspondence to Dr. M. Pilar Vinardell, Unitat de Fisiologia, Facultat de Farmacia, Av. Joan XXIII s/n, 08028 Barcelona, Spain. E-mail: [email protected]