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Abstract
Thirteen blood samples of thallium-poisoned people were cytogenetically investigated. The thallium concentration in blood varied from 25 to 2700 mug/L. The mean frequency of chromosomal aberrations in the poisoned group significantly exceeded our control level (7.08 +/--2.19% and 2.03 +/--0.25, p < .001). The rate of single fragments was significantly higher in poisoned group (7.77 +/- 2.68% and 1.59 +/- 0.23% , p < .001) while the frequencies of other types of chromosomal aberrations were similar in both groups. It is possible that thallium is an S-dependent clastogenic agent because the majority of the structural aberrations are of the chromatid type. Irrespective of mechanisms, damage to genetic material was revealed in thallium-poisoned people.