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Abstract
A computer program was developed using Rhee, Aris and Amundson's multicomponent chromatography theory to simulate product-withdrawal, moving feed, and moving-port chromatography for both adsorption and ion exchange systems. Moving-withdrawal chromatography was found to reduce significantly the cycle time and solvent usage, improve throughput, and increase the product concentration of the slowest moving species. This method is more effective for systems with wide ranges of affinities. Moving-feed chromatography does not give significant improvement over conventional chromatography processes with short concentrated feed impulses. Dilution of feed with solvent should be avoided in order to obtain concentrated products.