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Abstract
The ‘URL File Not Found’ message is all too familiar to users seeking biomedical information on the Web, and occurs when a requested Web‐site is no longer available. The complex and dynamic nature of information flow is grounded in computer server technologies and makes the Web difficult to preserve. Enhancements in Web‐technologies are helping to improve the problem of Web‐site transience. Some initiatives to manage Web‐site loss include Google's memory cache, the Internet Archive with Wayback Machine, and Web‐site recording tools such as Internet Researcher.