Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity

Abstract

The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin.

Keywords:

• Cisplatin
• acetyl l-carnitine
• apoptosis
• uterine tube

Acknowledgements

This work has supported by Gazi University Scientific Research Project Unit, Ankara, Turkey [grant number: 01/2010-20].

Disclosure statement

The authors report no declarations of interest.