Human papillomavirus: present and future perspective in Saudi Arabia

Abstract

Human papillomavirus (HPV) is a widely dispersed DNA double-stranded carcinogenic virus worldwide. Many cancers have been attributed to HPV subtypes as a major aetiological factor. Around 90% of cervical cancers have been attributed to the HPV infection, in addition to other cancers such as head and neck cancer, breast cancer and other cancers. As the carcinogenic high risk and low-risk, HPV subtypes are sexually transmitted viruses, and the Saudi community is religiously conservative, lots of measures of the precise burden of the HPV and its related cancers are still obscure. With the absence of cervical-screening programmes and in-depth research in HPV-related cancers, there a lack of literature except for literature pertained to awareness and perceptions. Consequently, the present review is deemed to explore the present state of the HPV-related issues, the future perspective in light of the current scientific evidence, as well as, Saudi community practices, and health policies in this regard. Making accessible data on HPV-related cancers can assist in designing HPV-related early detection and control sustainable programmes. Therefore, this review aimed to discuss the most important magnitudes related to the HPV, concerning the available literature from Saudi Arabia and the data in the neighbouring Arab countries interrelated to Saudi Arabia. The review depended on searching Electronic databases using strongly considered indexes including PubMed, Medline, Web of Science, Scopus, ABSCO, EMBASE, and others. In conclusion, though Saudi Arabia is pronounced as a conservative community with low sexual transmitted diseases, there is an alarming menace of HPV-attributable diseases necessitating a quick intervention.

Keywords:

• Epithelial ovarian cancer;
• PIK3CA mutation
• p110α expression
• FIGO stage
• Kaplan-Meier survival analyses
• Saudi Arabia

Acknowledgements

The author thanks Dr. Abdullah Alotaibi, College of Medicine, University of Hail, Kingdom of Saudi Arabia for his valuable comments on the text.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Study was registered at College of Applied Medical Science, Jouf University, Saudi Arabia. Reference Number: EC-0005/CM/JU.01/19.