Intrahepatic cholestasis of pregnancy: from an obstetrician point of view

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is the commonest among the specific dermatoses of pregnancy. The disease is characterised by intense pruritus and specifically by elevated bile acid levels and owing to the rarity of data published in this context, the disease carries a great challenge in both diagnosis and management. The disease is associated with significant maternal as well as perinatal adverse effects, hence, this article aims at improving the knowledge of the women’s health carers with the up-to-date and evidence-based, whenever possible, recommendations while managing patients with ICP.

Keywords:

• Intrahepatic cholestasis
• bile salts
• meconium stained
• ursodeoxycholic acid
• foetal demise
• premature birth

Author contributions

Guaranteeing Author: Mohsen M A Abdelhafez. Contributorship: Mohsen MA Abdelhafez and Karim AM Ahmed were responsible for conceptualising the study and reviewing the literature. Aya M. Eldiastey, Fairrul Kadir, Firdaus Hayati were involved in secondary data collection, interpretation of studies, and manuscript drafting. Dg Marshita Pg Baharuddin, Win Win Than and Mohammad Saffree Jeffree were critically analysing literature and expert input in synthesising knowledge and Mohd Nazri Bin Mohd Daud and Kai Xin, Tay finalising the manuscript’s content. All authors reviewed and edited the manuscript and approved the final version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).